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1、Cell retinoic acid binding protein and tumor related research. PDF, 68,Chemistry of life, 31, 2011Low Mini ReviewCHEMISTRY OF LIFE 2011,31 (1)Article number: 1000-1336 (2011) 1-0068-04The cell retinoic acid binding protein and tumor researchYang FangThe college of agriculture and life sciences, anka
2、ng 725,000Abstract: cytoplasmic acid binding protein (CRABP) was used to interact with the nucleotropic receptor on cytoplasmic acid and nucleus, while promoting retinoic acidMetabolic enzyme activity, enhanced the conversion rate of retinoic acid. CRABP contains two highly homologous proteins in ve
3、rtebrate cells: CRABP1 andCRABP2. CRABP is a protein with low molecular weight and is highly conservative. Existing studies have shown that in many tumors. CRABP genetic abnormalitiesGene expression levels are different from normal tissue; . The abnormal methylation of the CRABP was associated with
4、low survival rates in some tumours, CRABPBecause it can be a common target for tumor diagnosis and prognosis.Keywords: retinoic acid binding protein; Methylation. Tumor; Molecular targetsMiddle image classification number: Q75Retinoic acid (RA) is A vitamin A (retinol)Derivatives, the ligand of the
5、important nuclear receptor family, are presentThe most important of the inductive agents found, for various organizations,Cells have a strong induced differentiation and are widely used in tumorsChemical treatment. The chemical properties of retinoic acid are not stable and fatSolubility, therefore,
6、 must be in the process of absorption, transport, and secretionSpecial proteins combined. Its physiological functions are mainly composed of two types of proteinsQualitative mediated, namely: retinoic acid receptor and retinoic acid binding protein. retinoicThe retinoic acid receptor (RAR) includes
7、RAR a, RARb, and.RARg and retinoic acid X receptors.B, g. Cellular retinoic acid - bindingProtein, CRABP, is a cytoplasmic medium retinoic acid molecule and nucleusThe important substances that interact with the nucleate receptors in the yellow acid. In this paper, the mainTo discuss the progress of
8、 the research on retinoic acid binding protein and tumor.Retinoic acid binding proteinIn vertebrate cells, the cell retinoic acid binding protein(CRABP) contains two highly homologous proteins. - CRABP1 andCRABP2. CARBP is involved in transshipment RA and its metabolismDegree of conservative. The CA
9、RBP sequence is highly conservative, and the mouse and cows CRABPThe basic amino acid sequence of the surface site is the same as the CRABPRelease date: 2010-08-04The shaanxi provincial education hall natural science fund (08JK210) and ankang collegeFunding for the high-level talent research initiat
10、ive (AYQDZR200805)Author: Yang fang (1974 -), female, master, lecturer, communications writer,E-mail:Theres one amino acid thats different from 1. In embryonic tissue, two proteins are widely usedUbiquitous, but usually not expressed in the same cell. In the adult,CRABP1 is widely expressed in the b
11、ody and the expression of CRABP2 is limitedThe skin, uterus, ovaries, lateral ventricle plexus, some cholinergic nerveYuan and soft meninges.The dynamic study shows that the mechanism of the transfer of yellow acid into the nucleus is transferredDifferent. CRABP1 is a passive transhipment of retinoi
12、c acid transportThe concentration gradient of ligands. CRABP2 is the inverse concentration gradientActive transport, which transports RA through direct collision. CRABPThere are three points in the role of RA: (1) the role of the closed RA activity;(2) to transfer RA to the particle body oxidase deg
13、radation; (3) would transmit the RAPass the nucleus. CRABP1 and RA have more affinity than CRABP2,But the lack of a CRABP2 gene can lead to a ratio of CRABP1 to CRABP1Because of more serious phenotype changes. .1.1 CRABP1The coding section of CRABP1 is located in 15q24. People CRABP1 by 137An amino
14、acid. CRABP1 is mainly used to improve RA metabolismThe production of CYP26A1 assists the retinoic acid in the cell endoplasmic reticulumThe pigment P 450 enzyme degrades 2, 3, and negatively regulates the activity of RA. When retinoicAfter the combination of acid and CRABP1, the reaction of the cor
15、puscular enzyme to retinoic acid is promotedShould be, produce a variety of products, such as 3, 4-didehydrogenation, 4-hydroxy, 4-oxygen(dai) and 18 - hydroxyretinoic acid. CRABP1 and CRABP2 table cellsThe levels are mainly regulated by RA and T3. 3. CRABP1 by retinoic acidBut sensitivity is a little bit worse than CRABP2.Chemistry of life, 31, 2011Small review.CHEMISTRY OF LIFE 2011,31 (1), 69,1.2 CRABP2The coding section of CRABP2 is 1q21-23. People CRABP2 by138 amino acids. A
