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1、This reaction allows aryl carbon heteroatom bond formation via an oxidative coupling of boronic acids stannanes or siloxanes with N H or O H containing compounds in air Substrates include phenols amines anilines amides imides ureas carbamates and sulfonamides The reaction is induced by a stoichiomet
2、ric amount of copper II or a catalytic amount of copper catalyst which is reoxidized by atmospheric oxygen or another primary oxidant The Chan Lam Coupling may be conducted at room temperature in air which gives it a certain advantage over the Buchwald Hartwig Cross Coupling Mechanism of the Chan Lam Coupling The reaction with a stoichiometric amount of copper II is also facilitated by oxygen because reductive elimination from a copper III species is faster Recent Literature
