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1、肠道菌群与代谢疾病 目录 肠道菌群与健康和疾病概述肠 脑轴肠 肝轴肠道菌群与代谢性疾病 肥胖 糖尿病肠道菌群与肠病肠道菌群与免疫肠道菌群与其它疾病革命带来的挑战和机遇 一篇值得关注的综述 Naturereviews Microbiology最新的影响因子为22 490 2013 人菌共生 KristinaHarris etal IstheGutMicrobiotaaNewFactorContributingtoObesityandItsMetabolicDisorders JournalofObesity Volume2012 p1 14 人肠道菌群种类和数量 EAMONNM M QUIGLE
2、YandRODRIGOQUERA SmallIntestinalBacterialOvergrowth RolesofAntibiotics Prebiotics andProbiotics GASTROENTEROLOGY2006 130 S78 S90 好细菌和坏细菌 菌群是健康的核心 NathalieM Delzenne etal Targetinggutmicrobiotainobesity effectsofprebioticsandprobiotics Nat Rev Endocrinol 7 639 646 2011 肠道菌群对人生理的影响 肠道菌群 代谢产物 功能 Jeremy
3、K Nicholsonetal Host GutMicrobiotaMetabolic Science336 1262 1267 2012 影响肠道菌群的因素 NathalieM Delzenne PatriceD Cani InteractionBetweenObesityandtheGutMicrobiota RelevanceinNutrition Annu Rev Nutr 2011 31 15 31 影响肠道菌群的因素 肠 脑轴 脑 肠轴 GermFree GF MiceDisplayIncreasedMotorActivityandReducedAnxiety LikeBehavi
4、or resultssuggestthatthemicrobialcolonizationprocessinitiatessignalingmechanismsthataffectneuronalcircuitsinvolvedinmotorcontrolandanxietybehavior 肠 脑轴的概念 AugustoJ Montiel Castro etal Themicrobiota gut rainaxis neurobehavioralcorrelates healthandsociality FrontinIntegNeuro Oct2013 Vol7 Article70 1 1
5、6 脑 肠轴 肠 脑轴 迷走神经 SueGrenham etal Brain gut microbecommunicationinhealthanddisease FrontiersinPhysio GastrointSciDec2011Vol2p1 15 肠脑轴 脑肠轴 Q AZIZ etal Gutmicrobiotaandgastrointestinalhealth currentconceptsandfuturedirections NeurogastroenterolMotil 2013 25 4 15 菌群影响神经功能 EamonnM M Quigley Dopatientswit
6、hfunctionalgastrointestinaldisordershaveanalteredgutflora TherAdvGastroenterol 2009 2 Suppl1 S23 S30 菌群紊乱致焦虑和抑郁 JaneA FosterandKaren AnneMcVeyNeufeld Gut brainaxis howthemicrobiomeinfluencesanxietyanddepression TrendsinNeurosciences May2013 Vol 36 No 5 P305 312 精神活动影响肠道菌群 JasonA Hawrelak9 2 180 197
7、exposuretopsychologicalstressresultsinasignificantreductionintheproductionofmucinandadecreasedpresenceofacidicmucopolysaccharidesonthemucosalsurface 应激 压力引起胃肠疾病 P C KONTUREK etal STRESSANDTHEGUT PATHOPHYSIOLOGY CLINICALCONSEQUENCES DIAGNOSTICAPPROACHANDTREATMENTOPTIONS JPHYSIO PHARM2011 62 6 591 599
8、 脑肠轴紊乱导致溃疡 P C KONTUREK etal STRESSANDTHEGUT PATHOPHYSIOLOGY CLINICALCONSEQUENCES DIAGNOSTICAPPROACHANDTREATMENTOPTIONS JPHYSIO PHARM2011 62 6 591 599 应激导致IBD P C KONTUREK etal STRESSANDTHEGUT PATHOPHYSIOLOGY CLINICALCONSEQUENCES DIAGNOSTICAPPROACHANDTREATMENTOPTIONS JPHYSIO PHARM2011 62 6 591 599 应
9、激导致IBS P C KONTUREK etal STRESSANDTHEGUT PATHOPHYSIOLOGY CLINICALCONSEQUENCES DIAGNOSTICAPPROACHANDTREATMENTOPTIONS JPHYSIO PHARM2011 62 6 591 599 慢性疲劳与肠 脑轴 肠道菌群和自闭症 GIbarrierdefectsandmicrobiotaalterationsinthematernalimmuneactivation MIA mousemodelthatisknowntodisplayfeaturesofASD OraltreatmentofM
10、IAoffspringwiththehumancommensalBacteroidesfragiliscorrectsgutpermeability altersmicrobialcomposition andamelioratesdefectsincommunicative stereotypic anxiety likeandsensorimotorbehaviors autism andlikelyotherbehavioralconditions arepotentiallydiseasesinvolvingthegutthatultimatelyimpacttheimmune met
11、abolic andnervoussystems andthatmicrobiome mediatedtherapiesmaybeasafeandeffectivetreatmentfortheseneurodevelopmentaldisorders thesefindingssupportagut microbiome brainconnectioninamousemodelofASDandidentifyapotentialprobiotictherapyforGIandparticularbehavioralsymptomsinhumanneurodevelopmentaldisord
12、ers ElaineY Hsiao etal MicrobiotaModulateBehavioralandPhysiologicalAbnormalitiesAssociatedwithNeurodevelopmentalDisorders Cell155 1451 1463 肠 脑轴和自闭症 CarolineG M deTheije etal Pathwaysunderlyingthegut to brainconnectioninautismspectrumdisordersasfuturetargetsfordiseasemanagement EuropeanJournalofPhar
13、macology668 2011 S70 S80 肠 肝轴 EamonnM M Quigley GutBacteriainHealthandDisease Gastro HepatVol9 9 2013 P560 569 1998年马歇尔提出了 肠 肝轴 的概念 对肠道和肝脏功能关系的认识提示新的治疗理念 为肠道和肝脏疾病的治疗探寻新的治疗靶点 肠 肝轴之间的互动肠道菌群失调 大量G 杆菌繁殖 LPS产生显著增多肠粘膜屏障功能受损 致病菌和LPS大量移位 经门静脉入肝 损害肝功能 肝功能异常KCs代谢和清除LPS降低 导致肠道功能异常 GakuheiSon etal Contributiono
14、fGutBacteriatoLiverPathobiology GastroeResandPrac Vol2010 ArticleID453563 13pages 肠肝对话 肠道菌群致非酒精性脂肪肝 ValentinaTremaroli FredrikB ckhed Functionalinteractionsbetweenthegutmicrobiotaandhostmetabolism NATURE VOL489 13SEPTEMBER2012 肠道菌群导致脂肪肝 CarmineFinelliandGiovanniTarantino NONALCOHOLICFATTYLIVERDISEAS
15、E DIETANDGUTMICROBIOTA EXCLIJournal2014 13 461 490 肝脏疾病和SIBO 肠道菌群与代谢性疾病 肠道菌群增加能量储存 NathalieM Delzenne PatriceD Cani InteractionBetweenObesityandtheGutMicrobiota RelevanceinNutrition Annu Rev Nutr 2011 31 15 31 肠道菌群导致能量聚集 PatriceDCaniandNathalieMDelzenne Interplaybetweenobesityandassociatedmetabolicd
16、isorders newinsightsintothegutmicrobiota CurrentOpinioninPharmacology2009 9 737 743 肠道菌群引发多种代谢疾病 肠道菌群和肥胖 肠道菌群和肥胖是一个新的热门话题 肥胖的定义 肥胖病一般被定义作为有BMI30以上 体重将近900磅 约400公斤 的里基 RickyNaputi 现年39岁 是世界最重的男子之一 因为体型过于笨重而难以移动 他已经在坐落于太平洋关岛的家中躺了五年之久 肥胖和正常人 AmandineEverard PatriceD Cani Diabetes obesityandgutmicrobiota BestPractice ResearchClinicalGastroenterology27 2013 73 83 史氏甲烷短杆菌和肥胖 为了确定肠道菌群的改变和验证人体肠道中的乳杆菌或双歧杆菌是否与肥胖或消瘦相关 我们采用定量PCR和乳杆菌选择性培养基分析了68位肥胖志愿者和47位对照的粪便菌群中硬壁菌 拟杆菌 乳酸乳球菌 动物双歧杆菌和若干乳杆菌种的数量 结果 定量PCR试验中 动物双歧
