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1、(pressureequilibrium)”?p,B+u,yN,!5gWZ;AV,B5j;V|=*su*,$。ID1ZhengHP, WangHQ,ZhangFH,etal.AnatomicBasisofPerforatingBranchFlapsofMedialVastusMuscleJ.Microsurgery, 2008, 28(1):61-642BerteliJA, KhouryZ.Neurocutaneousaxialislandflapintheforearm:anatomicalexperimentalandpreliminaryclinicalresult.BrJPlastSu
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3、b+307D(7、t)(:、BT)YT:,0Q:;t,0Q:suhang-FKGF-2lM8llT付文亮王园园王金凤邢微微徐涛袁顺宗朱泽轶洪明金哲邹民吉苏航徐东刚K1)FKGF-2lM8060Co&vll*T。ZE|lsF、F、FKGF-2lM8F!F。60CoLbFFl&v,946.5Gy。Viq、3ilFhMZsFKGF-2lM8rT。TFKGF-2lM8FiqA!FF;hM4TAU,FKGF-2lM80?l%93,Fys*。FKGF-2lM8F、S9AzF。FKGF-2lM80VA4iq,60CovllFzT。1oMFKGF-2*iqStudyonthePreventionandTrea
4、tmentoftheSmallIntestineRadiationDamageinRatsbyRecombinantHumanKGF-2Mutant.FuWenliang,WangYuanyuan,WangJinfeng,XingWeiwei,XuTao,YuanShunzong,ZhuZeyi,HongMing,JinZhe,ZouMinji,SuHang,XuDonggang.InstituteofBasicMedicalSciences, AcademyofMilitaryMedicalSciences, Beijing100850, ChinaAbstractObjectiveToex
5、plorethepreventioneffectoftherecombinanthumanKGF-2mutantforintestinemucosaldamagecausedbywholebodyradiationof60Co.MethodsTheMiceweredividedintonormalgroup, modelgroupandothertwogroupsadmin-60 JMedRes,Dec2010,Vol.39No.12istratedbyrecombinanthumanKGF-2mutantorAnduolin.Thenallmicewereirradiatedby60Cowi
6、ththedoseof6.5Gy.TheeffectofrecombinanthumanKGF-2mutantcanbeanalyzedthroughthesurvivalrate, livingstatusandpathologicaltissuesliceofsmalintes-tine.ResultsThesurvivalrateofrecombinanthumanKGF-2mutantgroupwassignificantlyhigherthanthatofbothgroupsofAnduolinandmodel.Theresultsofpathologicaltissueslices
7、howedthatadministrationoftheKGF-2mutantcouldpromotetheproliferationofin-testinalcryptcells, andrestoretheinjuredintestinalmucosa.Whatsmore, miceinrecombinanthumanKGF-2mutantgroupweresig-nificantlybetterthanthoseinthemodelgroupintermsofmorphologicalindexoffurcolor, actionstatusandsoon.ConclusionThere
8、-combinanthumanKGF-2mutantcansignificantlyincreasethesurvivalrate, andhasgoodpreventionandtreatmentefectinmicewithinjurycausedbyradiationof60Co.KeywordsMutantofhumanKGF-2;Radiationdamage;Mucosalrepair;Survivalrate*bL,V*,p?,%,*,9F,K=2i?。%3y0-2(keratinocytegrowthfactor-2,KGF-2)98%3y0-10(fibroblastgrow
9、thfactors-10,FGF-10),8%3y0(fi-broblastgrowthfactors, FGFs)EBB1。V,KGF-2?+s%3、93%M,7*ZzrT 26 ,$7?b*0。-KGF-2T,BFKGF-2lM8STEA7 。F60Co&svBABL/cl80,NsvllT,iXg0!rT1。ZE1.k4:FKGF-2lM8i!;60CoLvSb+YDSbD4;3k4(SsB。2.L:b)BALB/cl96, 6 8(202g),Sb+YDSLI|:XK(+)-2007-007。L-!3?,4s,58VE|s4F:F(10)、F(22)、FKGF-2lM8F(22)、!vF(22)、FKGF-2lM8h4F(10)h4F(10)。3.v#0:60CoLb(b+YDSbCo)FFlv,946.5Gy,v5m,vq2.446G
