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1、Chapter 10 Nuclei and Chromosomes 细胞核和染色体 4 Medical Cell Biology Jing Changqin 井长勤 associate professor E mail jingchangqin Medical Cell biology2 Section four Nucleolus 核仁 Medical Cell biology3 4 1 General information of Nucleolus vStructure Have no membrane vNumber one or many vLocation center or ve
2、rge Medical Cell biology4 Fibrillar centers Dense fibrillar component Granular component Nucleolus Matrix 4 2 structure of nucleolus Medical Cell biology5 envelope nucleolus ten loops with rDNA at interphase cutting Part of nucleolus with chromatin loops 4 2 structure of nucleolus Medical Cell biolo
3、gy6 Nucleolus organization region NOR vChromosomes organizing to form nucleolus vD group 13 14 15 G group 21 22 vContaining rDNA rRNA gene Medical Cell biology7 4 3 function of nucleolus v Ribosomal Biogenesis pre rRNA synthesisProcessAssembly FC DFCDFC GC Cytosol Directional process Medical Cell bi
4、ology8 vCharacteristics of RNA transcription vNORs in human chromosomes 13 14 15 21 22 vCode for in eukaryotes 18s 28s 5 8s rRNA 4 3 function of nucleolus Medical Cell biology9 vSynthesis and processing of rRNA precursor vCleavage of pre rRNA 4 3 function of nucleolus Medical Cell biology10 Synthesi
5、s and processing of 5s rRNA v5s rRNAs are encoded by a large number genes Human 2000 v5s rRNA gene are located outside the nucleolus v5s rRNAs are transcibed by RNA poly III vThe 3 end of 5s rRNA is removed during processing Medical Cell biology11 The assembly of ribosomes Medical Cell biology12 4 4
6、 nucleolar cycle v The nucleolus disappears during mitosis Medical Cell biology13 4 4 nucleolar cycle Medical Cell biology14 Summary for nucleolus vGeneral information vstructure of nucleolus vfunction of nucleolus vnucleolar cycle Medical Cell biology15 Section five Function of Nucleus 细胞核的功能 Medic
7、al Cell biology16 6 1 importance of DNA and nucleus vAngelman syndrome vPrader Willi syndrome vdel 15 q11 q13 vDeletion from mother then AS vDeletion from father then PWS Medical Cell biology17 6 2DNA mainly located in nucleus vGenome size generally increases with an organism s complexity vC value p
8、aradox Medical Cell biology18 6 3 DNA replication vsemiconservative replication vsemidiscontinuous replication vRNA primer vEnzymes and protein Medical Cell biology19 6 4 DNA transcription vSense chain and antisense chain vProcessing of pre RNA vRegulation of the process of transcription Operon cis
9、acting element and trans acting factor Medical Cell biology Summary vNucleolus vFunctions of nucleus 20 Medical Cell biology21 Summary for nucleus vPreface vStructure vNuclear envelope vChromatin vChromosome vNucleolus vFunction Medical Cell biology22 Exercise 1 1 Explain the key wordsExplain the ke
10、y words nucleolus nucleolus 2 2 What are the functions of nuclei What are the functions of nuclei Medical Cell biology23 1 翟中和等主编 细胞生物学 第3版 高等教育出版社 2007 2 韩贻仁主编 分子细胞生物学 第3版 高等教育出版社 2007 3 艾伯茨等著 赵寿元等译 基础细胞生物学 上海科学技 术出版社 2002 4 王金发 细胞生物学 科学出版社 2004 5 杨 恬 细胞生物学 人民卫生出版社 2005 6 Karp G Cell and Molecular
11、Biology 4th ed 2005 高等教 育出版社 2007 7 Lodish H et al Molecular Cell Biology 4th ed W H Freeman and Company 2000 References and websites Medical Cell biology24 1 2 http 202 116 64 20 wjf index htm 中山大学 3 http 221 10 254 145 204 show asp id 49 川大 4 5 http www bio 6 http www xa 7 http www bio medicine org 8 http www ncbi nlm nih gov 9 Medical Cell biology
