《病理生理学-第十二章细胞凋亡与疾病（pathophysiology - chapter twelfth apoptosis and disease）》由会员分享，可在线阅读，更多相关《病理生理学-第十二章细胞凋亡与疾病（pathophysiology - chapter twelfth apoptosis and disease）（16页珍藏版）》请在金锄头文库上搜索。
1、病理生理学-第十二章 细胞凋亡与疾病（Pathophysiology - Chapter twelfth apoptosis and disease）The twelfth chapter is apoptosis and diseaseFirst, the multiple-choice questionType A problem1. which of the following is wrong about the description of apoptosis?A. cell necrosisProgrammed cell death in B. cellsThe active su
2、icide process of C. cellsThe pervasive phenomenon of life in D.E. basic cytologic events or processes2. the inducing factors of apoptosis areA.EB virusB. high temperatureC. estrogenD. nerve growth factorE. phenobarbital3., the inhibitory factors of apoptosis areA. cell growth factorB. cytotoxic T ly
3、mphocyteC.HIV infectionD. ionizing radiationE. secretes large amounts of glucocorticoids4. genes that promote apoptosis areA.Bcl - 2B.p53C.EIBD.ced - 9E.IAP5., apoptosis attenuation disease hasA. leukemiaB. Parkinsons diseaseC. aplastic anemiaD. heart failureE. viral hepatitis6. apoptosis enhancing
4、diseases areA. primary liver cancerB. systemic lupus erythematosusC. prostate cancerD. insulin-dependent diabetes mellitusE. senile dementia7. which of the following is wrong with regard to the morphological features of apoptosis?A. is the loss of a single cellThe B. cell membrane is intactC. cells
5、swell and dissolveD. cell contents were not releasedE. lysosomes are relatively intact8. which of the following is not true of the difference in biochemistry between cell apoptosis and cell necrosis?A. needs energyB. requires the synthesis of nucleic acids and proteinsC. has new gene transcriptionD.
6、 chromatin showed non random degradation and showed a DNA ladder like bandLoss of steady-state regulation of E. ion9. which of the following is wrong with regard to the description of apoptotic bodies?A. is formed by invagination of the cell membraneThe size and composition of B. are exactly the sam
7、eOnce C. is formed, it is quickly devouredD. contents are not leakedE. is characteristic morphological change of apoptotic cells10. which one of the following is wrong about the description of PCD?A. cells are pyknosis and split into bodiesThere was no change in B. mitochondriaC. chromatin condenses
8、 and electron density increasesD. nuclear DNA electrophoresis showed no ladder like behaviorAutophagy is often present in E.11. which of the following processes belongs to apoptosis?Emergence of A. tobacco angular wormsMetamorphosis of B. silk moth larvaeEvolution of C. labial glandsD. castration of
9、 the prostate glandE. cell death during acute ischemia12. which of the following is true about the cleavage of DNA during apoptosis?A. is cut by an endogenous proteaseB. chromatin DNA is completely random degradedC.DNA cleavage fragments were inversely proportional to the number of apoptotic cellsD.
10、 mitochondrial DNA also degradesThe E. enzyme was cut at the nucleosome junction of DNA13. which of the following does not include the recognition and phagocytosis mechanisms of phagocytes on apoptotic cells?A. lectin on the surface of phagocytes can recognize the change of surface sugar in apoptoti
11、c cellsB. has CD36 on the surface of phagocytesC. is alpha beta cell phagocytosis by 3 integrinD. reduced the platelet surface reactive protein on apoptotic cellsThe asymmetric distribution of phospholipids on the membrane of E. apoptotic cells was disrupted14. which of the following is not true abo
12、ut T cells and apoptosis?A.90%95% thymocytes are removed by apoptosisB. is removed by apoptosis and is a T cell that reacts with an autoantigen of the MHC polypeptideC. cytotoxic T cells by secreting perforin mediated target cell apoptosisD. cytotoxic T cells mediate the apoptosis of target cells th
13、rough the secretion of granzymeE.T cells cause apoptosis through the Fas-Fas ligand pathway15. which of the following is wrong with regard to the apoptotic protease?A. has a specific hydrolysis effect on the substrate aspartic acid siteThe B. active site is rich in cysteineC. activates an inhibitor
14、of apoptosis (e.g., Bcl-2)Protein structure of D. hydrolyzed cells,Lead to cell disintegrationE.ICE and CED-3 have greater homologyType B problemA. cells swell and dissolveB. nucleus DNA electrophoresis showed ladder mapC. mitochondrial pyknosisD. often have a mitochondrial autophagy.There was no ch
15、ange in E. chromatin1.PCD showed2. apoptosis is manifested asThe necrosis of 3. cells is characterized byType C problemA. tumor necrosis factor familyB. cell growth factorC. bothD. neither1. the inducing factors of apoptosis are2., the inhibitory factors of apoptosis areA. cells are pyknosis and split into bodiesB. is a mitochondrial autophagy.C
