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1、Distribution of arterial stenosis in acute stroke and risk factors,Peking University First Hospital Department of Neurology Dr. and Prof. Huang Yining huangyn,Background,There is high incidence of intracranial arterial stenosis in Chinese stroke patients. It is assocated with poor outcome in those w
2、ith arterial stenosis comparing with those without stenosis. Many risk factors are proved, i.e. age, gender, Hypertension, diabetics.,Question and Purpose,China is a huge country. There are great difference in the geography, life styles, economic development from regions to regions. Whether the cere
3、bral arterial stenosis is depended on regional distribution? Whether the stenosis is depended on economic development?,Standard management of acute stroke 10th five year National Project Sponsored by National Scientific Committee No：2001BA703B11 A multicenter study,Data and methods,Inclusion criteri
4、a,First time of acute ischemic Admitted in SU and department of neurology Within 7 days after onset NIHSS 5 Involvement of anterior or posterior circulation Content agreement,Grouping for Statistic analysis,With/ without arterial stenosis Extracranial group/ intracranial group Anterior / posterior c
5、irculation Anterior circulation: CCA, ICA, TICA, MCA, ACA Posterior circulation: Sub A, VAe, VA, BA, PCA Logistic regression: regions, size of hospitals, age, gender , HTN, DM, LIPID,End-point,Modified Rankin Scale in discharge， and follow-up in month 3 and month 6 good outcome: mRS 2 poor outcome:
6、mRS 2,Results and Analysis,Descriptive statistics of data,1273 cases enrolled 1063 83.5% underwent vascular examination Age : 61.811.0 yrs Male: 833 (65.4%) Follow up: 1185/ 1273 ( 93.1%) in month 3 1149/1273 (90.3%) in month 6,Ratio of arterial involvement,568 (53.4%) cases with arterial involvemen
7、t: Male: 374 ( 65.8%) Female: 194 (34.2%),Stenosis and Economic Development,Classify the hospitals as 3 classes: Class 1, those from richer regions Class 2, those from moderate regions Class 3, those from poorer regions The patients living in the rich regions had higher incidence of arterial involve
8、ment OR=0.856 ( 95% CI, 0.751-0.976,p=0.040 ),Stenosis and Economic Development,patients in the hospitals of class I is older than in class II and III Class I age= 62.5511.19 yrs Class II age= 60.4712.10 yrs Class III age= 60.7210.55 yrs Between groups (ANOVA): F=4.367 p=0.013,CONCLUSIONS,Living environment is significantly related to the cerebral arterial involvement. The patients living in relatively “rich regions” suffered from higher incidence of arterial stenosis. It is independent on age, gender, HTN, DM, or Lipid profile.,
