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1、药物中间体电合成技术的研究与应用X阚显文, 赵广超, 胡斌, 方宾(=SvS,241000)K1:80W8/,VaWa#2EZ/0W8bID43b1oM:;0W8;2oms|: O625,O626,TQ46DSM: AcI|: 1005-1511(2002) 05-391-06Study and Applycation of Electrosynthesisin Pharmaceutical IntermediateKAN Xian-wen,ZHAO Guang-chao,HU Bin,FANG Bin( College of Chemistry and Material Science, A
2、nhui Normal University, Wuhu 241000, China)Abstract: The study and application of electrosynthesis in the synthesis of pharmaceutical in-termediate was reviewed with 43 refrences through four sections: direct electrosynthesis, in-direct electrosynthesis, paired electrosynthesis and ultrasonic electr
3、osythesis.Keywords: electrosynthesis; ultrasound wave; electrochemistry; pharmaceutical intermedi-ate; synthesis0aa%h8? 1bW8,15,ZE,Ea3EbtZEiV,aqbyN,M?70MClark 2 ,Ito 380MWalton 442ZE00W8btZE|0Tk40W8,vha,Ovh,FyQ,VeQb0W8ZE,|EVZ/0W8b1EQc0M,|tQ+,PQ?3,S,EbJY|: Chan 5hMJY2-(6-J-2-&)2-(s)(Y02-YdW8)bArOeArO
4、- e, 2CO2i391iChinese Journal of Synthetic ChemistryXl: 2001-08-20;: 2001-11-04:SES/( 00177)Te:A( 1975- ) ,o,qB,aS,=SvSV3,1VY#sbY:Z_( 1947- ) ,3,L,=SvSq,V3=,VY,sbT el: ( 0553) 3869302ArCO-2CO2HH3O+ArOHCO2HAr= MeO - , -|:A 6#T|,DL-(DL-HC),ADL-;=( DL-HCT) (10W8,V!MR-2407, Citiolone0)bNH2CO2S HSNH2CO2H
5、+ 2H+ + 2e HCl2 HSNH2 HClCO2H2OS NH2 HCl + 2H2Ob&|:A 7Cu-HgCu- LiT,H2SO4Ab&+,53b&(C6H5NO),B3&(C6H5NHOH) ,K&V&p(e0YpW8)b NO2 + 2H+ + 2e NO + H2O NO + 2H+ + 2e NHOH NHOH H+HO NH26, 8 ,S 9 ,V 10910W8TMb2WEYVB.0Q,3S,NH,?3NM,M3,3VQQ,3S,NQ 11bZE+: (1)VQ?,Q,y74Q4bM1,V4qrq; (2)VP,Vih,y7Vh3,7O+bb2. 1氯代甲苯的间接电
6、氧化 12Mn2+ /Mn3+T&J,WsYo&Ja#o&Ja2, 4-=o&J2, 6-=o&J(o&JY0W8)bQ:Mn2+ Mn3+ + eQ:R2 R1+ 4Mn3+ + H2OR2 R1CHO+ 4Mn3+ + H+R1 Cl H ClR2 H Cl Cl2. 2甲苯间接电氧化法 13#T,H2SO4Mn2+T.4,bT,PJ&W&J(Y0W8)bQ:Pb2+ Pb4+ + 2e2Mn2+ + Pb4+ 2Mn3+ + Pb2+Q:Mn3+ + Mn2+ + CHO2. 3对甲基苯甲醚间接电氧化* 14Pb,;T,o_T4,20j40/Ce4+A|J&JP(Y0W8)bi392iV
7、ol.10,2002Q:Ce3+ Ce4+ + eQ:MeO + 4Ce4+ + H2OMeO CHO + 4Ce3+ + 4H+2. 43-氯-4-氟硝基苯间接电还原m 15L,0,Ti/TiO2T|, DSAT,|Wb3-o-4-b&o&(ara 40M?2oT/0W8bB 412oZn- HAc3B,?Zs001W8,BQ01ilb2?Z,X|2o+yT,V72Eb2Y1/+:VFy.q; VbV;VHbVY;q2VMV4,9v1VbJanson R. 42|HF2ob,VbNanakalF 431994M2&JVYb#|,;,J?A&J,/1:ArCHOe + H+2e + 2H+1/ 2 ArCH(OH)CH(OH)ArArCH2OH12sY?C
