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1、BRONCHIECTASIS,Zhiwen Zhu The 1st affiliated hospital of Sun Yat-sen university, pulmonary department,BRONCHIECTASIS,Definition Etiology Pathology Clinical presentation Diagnosis & differential diagnosis Treatment,Definition,Bronchiectasis is a condition anatomically defined by chronic, irreversible
2、 dilation and distortion of the bronchi caused by inflammatory destruction of the muscular and elastic components of the bronchial walls.,Etiology,Conditions associated with the development of bronchiectasis 1. Postinfection Bacterial pneumonia Tuberculosis Pertussis Measles Influenza,Etiology,2. Pr
3、oximal airway obstruction Foreign body aspiration Benign airway tumors Middle lobe syndrome Extrinsic compression by enlarged lymph nodes of the right middle lobe of the lung that obstructed bronchi and lead to right middle lobe atelectasis and recurrent infection.,Etiology,2. Proximal airway obstru
4、ction Foreign body aspiration Benign airway tumors Middle lobe syndrome Extrinsic compression by enlarged lymph nodes of the right middle lobe of the lung that obstructed bronchi and lead to right middle lobe atelectasis and recurrent infection.,Etiology,3.Abnormal host defense Ciliary dyskinesia (
5、Kartageners syndrome) Humoral immunodeficiency 4.Genetic disorders Cystic fibrosis 1- Antitrypsin deficiency 5.Others,Pathology,Dilation and distortion of the bronchi Damage of airway epithelium Dilation and hyperplasia of blood capillary,Clinical presentation,The production of large quantities of p
6、urulent and often foul-smelling sputum. The volume of sputum can be used for estimating the severity of the disease Mild 150 mL Dry bronchiectasis usually involve the upper lobes,Clinical presentation,2. Chronic cough 3. Hemoptysis: Frequent More commonly in dry variety Usually mild (blood streaking
7、 of purulent sputum) Massive hemoptysis is usually from dilated bronchial arteries or bronchial-pulmonary anastomoses under systemic pressure 4. Recurrent pneumonia: same segment 5. Systemic manifestations: fever, weight loss,Clinical presentation,Physical finding Early phases or dry variety: normal
8、 Severe or secondary infection: persisting crackling rales in the same part of lung Later stage: digital clubbing, emphysema, and cor pulmonale.,Evaluation,1.Roentgenographic studies The plain chest film: increased in size and number of bronchovascular markings (quiet nonspecific),Evaluation,1.Roent
9、genographic studies Bronchography: (traditional gold standard),Evaluation,CT or HRCT: high sensitivity and specificity Train track sign: the bronchial wall is thicken and visible; the bronchi lose the trend of narrowing from proximal end to distal end.,Evaluation,CT or HRCT: high sensitivity and spe
10、cificity Diamond ring sign: dilated bronchi appear as ring structures with internal diameters greater than those of their accompany pulmonary artery branches.,Evaluation,2.Bronchoscopy Evaluating the proximal airways for lesions. Assessing the cause of hemoptysis Localizing the source of hemoptysis,
11、Diagnosis,Symptoms Sign reontgenographic fiding,Differential diagnosis,Differentiate from: Chronic bronchitis No recurrent hemoptysis; CT scan Lung abscess X-ray/CT: local infiltrated shadow or cavitations with air-fluid level inside.,Differential diagnosis,Tuberculosis radiographic finding; sputum
12、anti-fast smear Congenital pulmonary cyst multi thin wall cavities without infiltration around.,Treatment,Medical management 1. Improving the drainage of airway 1) expectorant 2) bronchodilators 3) postural drainage,Anterior segment,Posterior segment of right upper lobe,Lower lobe,Treatment,Medical
13、management 1. Improving the drainage of airway 1) expectorant 2) bronchodilators 3) postural drainage 4) bronchoscopy,Treatment,Medical management 2. Antibiotic The choice of antibiotics should be accurately by the results of sputum culture and drug sensitivity test. Empirical therapy -antipseudomonal antibiotics.,Treatment,Surgical therapy Recurrent and refractory clinical symptoms are due to a focal area of disease involvement. Massive hemoptysis Management of hemoptysis,THANK YOU!,
