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1、Artemisinin A Gift from Traditional Chinese Medicine to the World Tu Youyou Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China Nobel Lecture, Dec 7, 2015 Karolinska Institutet 1 2 2 The Breakthrough in the Research of Artemisia annua L for Discover
2、y of Artemisinin Archive, Institute of Chinese Materia Medica 3 The elements analysis by the collaborative institution, Institute of Matria Medica, Chinese Academy of Medical Sciences, on April 27th, 1973. (Front side) Archive, Institute of Chinese Materia Medica 4 (Back side) The Molecular Structur
3、e and the Stereo-structure of Artemisinin 5 6 7 7 8 Molecular Structures of Artemisinin and its Derivatives 9 New drug certificate of artemisinin issued by the Ministry of Health (1986) (left) New drug certificate of dihydroartemisinin issued by the Ministry of Health (1992) (Right) 9Archive, Instit
4、ute of Chinese Materia Medica 10 Worldwide Attention to Artemisinin 11 Commitment to the Clearly Defined Goal 12 Knowledge is Prologue in Discovery 13 Antimalarial Collections of Recipes and Prescriptions April, 1969 Archive, Institute of Chinese Materia Medica A Handbook of Prescriptions for Emerge
5、ncies By Ge Hong 14 ? 15 Qinghao Has a Long History of Clinical Application 16 Simple Resarech Facilities in the 1970s 17 Invention Certificate for Progress in Anti-malarial Research Issued by National Congress of Science and Technology, 1978 Archive, Institute of Chinese Materia Medica WHO World Ma
6、laria Report 2014 The World Is Continuing to Make Impressive Progress in Reducing Malaria Cases and Deaths. Dr. Margaret Chan, 2014 18 Spread of P. falciparum Resistance to Artemisinin Ashley E A et al, Spread of Artemisinin Resistance in Plasmodium falciparum Malaria N Engl J Med. 2014, 371(5): 411
7、423 19 WHO Global Plan for Artemisinin Resistant Containment (GPARC) Goals and Recommendations WHO Global Plan for Artemisinin Resistant Containment, 2011 20 21 Chinese medicine and pharmacology are a great treasure-house. We should explore them and raise them to a higher level Hand writing by Mao Z
8、edong On the stork tower, Wang Zhihuan (Tang dynasty) 22 Finally, I would like to acknowledge all colleagues in both China and overseas for their contributions in the discovery, research and clinical application of artemisinin. I am grateful for all my family members for their continuous understanding and support. I sincerely appreciate your kind attention. Thanks you all! Acknowledgements 23
