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1、SICENCE 新闻发布 作者：Sung Ho Jang 稿号：NRR-D-14-00193首次提出脑创伤后损伤扣带束恢复的评估工具：弥散张量纤维束成像的客观验证来自韩国 Yeungnam 大学医学院的 Sung Ho Jang 教授等应用弥散张量纤维束成像评估发现， 1 例发病 2 周后表现为严重的认知障碍的 19 岁弥漫性轴索损伤女性患者，双侧胼胝体膝部前方的扣带束不连续。发病6 个月左侧扣带束延长至左侧基底前脑；右侧扣带束被一条通过胼胝体膝部前方的新纤维束，与左侧基底前脑相连接。此时其认知功能也明显改善。他们认为这些发生在双侧扣带束的弥散张量纤维束成像改变提示了患者损伤扣带的恢复。扣带束
2、是联系基底前脑与内侧颞叶的神经纤维束，包括起源于基底前脑 Meynert 基底核中间胆碱能通路，对于维持记忆功能十分重要。以往用常规脑 MRI 鉴定扣带束是不可能的，因为其不能将扣带束与其毗邻的结构辨别开。弥散张量纤维束成像可使扣带束三维可视化，从而用于扣带束的评估。许多 DTI 研究已报道了脑创伤后扣带束损伤，但脑创伤后损伤扣带束的恢复则几乎未见报道。此次 Sung Ho Jang 教授等首次应用弥散张量纤维束成像证实脑创伤后损伤扣带束的恢复，这一成果对于扣带束损伤和恢复的评估和诊断提供了帮助。文章发表在中国神经再生研究（英文版）杂志 2015 年第 2 期。Article: Recover
3、y of injured cingulum in a patient with traumatic brain injury by Sung Ho Jang1, Seong Ho Kim2, Hyeok Gyu Kwon1 (1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University 317-1, Daemyung dong, Namku, Daegu, 705-717, Republic of Korea; 2 Department of Neurosurgery,
4、 College of Medicine, Yeungnam University 317-1, Daemyung dong, Namku, Daegu, 705-717, Republic of Korea)Jang SH, Kim SH, Kwon HG (2015) Recovery of injured cingulum in a patient with traumatic brain injury. Neural Regen Res 10(2):323-324. 欲获更多资讯Neural Regen ResSICENCE 新闻发布 作者：Sung Ho Jang 稿号：NRR-D-
5、14-00193DTT first used for evaluation of recovery of injured cingulum in traumatic brain injury Prof. Sung Ho Jang, at Yeungnam University, Republic of Korea performed a study using diffusion tensor tractography (DTT) and found that a 19-year-old female with diffuse traumatic axonal injury presented
6、 with severe cognitive impairment and discontinuations of both cingulums anterior to the genu of corpus callosum at 2 weeks after onset. 6-month DTT images show that the left cingulum was elongated to the left basal forebrain and the right cingulum was connected to the left basal forebrain via a new
7、 tract that passed anterior to the genu of corpus callosum. At 6 months, the cognitive impairment was also significantly improved. They considered that these DTT changes of both cingulums appeared to indicate the recovery of both injured cingulums.The cingulum is the neural fiber bundle that connect
8、s the basal forebrain and medial temporal lobe. The cingulum contains the medial cholinergic pathway, which originates from the basalis nucleus of Meynert in the basal forebrain. Therefore, it is important for memory function. In the past, identification of the cingulum on conventional brain MRI has
9、 been impossible because it cannot discern the cingulum from other adjacent structures. DTT allows three-dimensional visualization and estimation of the cingulum. Many DTI studies have reported on injury of the cingulum following traumatic brain injury. However, very little is known about neural rec
10、overy of injured cingulums following traumatic brain injury. Prof. Sung Ho Jang was the first to use DTT to confirm the recovery of injured cingulum after traumatic brain injury. The authors believe that evaluation of cingulum using DTT would be helpful in the diagnosis of cingulum injury and in est
11、imating the changes of cingulum injuries in TBI. The relevant article was published in the Neural Regeneration Research (Vol. 10, No. 2, 2015).Article: Recovery of injured cingulum in a patient with traumatic brain injury by Sung Ho Jang1, Seong Ho Kim2, Hyeok Gyu Kwon1 (1Department of Physical Medi
12、cine and Rehabilitation, College of Medicine, Yeungnam University 317-1, Daemyung dong, Namku, Daegu, 705-717, Republic of Korea; 2 Department of Neurosurgery, College of Medicine, Yeungnam University 317-1, Daemyung dong, Namku, Daegu, 705-717, Republic of Korea)Jang SH, Kim SH, Kwon HG (2015) Recovery of injured cingulum in a patient with traumatic brain injury. Neural Regen Res 10(2):323-324.
